Sel lemak bertahan selama 8 tahun dalam badan kita, sebelum ia mati dan digantikan dengan sel2 baru. bagi orang yang mempunyai sel lemak berlebihan yg dah bertahun2, sel2 lemak diorang ni dah berubah struktur dan dah jadi berlainan daripada sel lemak orang2 yang bersaiz biasa.
Sel lemak yang sudah lama bertapak dalam badan kita ni, depa bina sistem pertahanan sendiri, & ia menjadikan depa menjadi VIP of the lemak dalam badan kita. Diorang tidak lagi menjadi bahan api dalam tubuh kita.
Diorang membina sejenis protin bernama Perilipin di sel lemak tu, yang jadi macam baju besi utk melindungi diorang. Kesannya, kita exercise & berdiet macamana pun, susah nak bakor lemak2 ni. Lemak degil namanya.
So, macamana nak buat ni? Takkan nak membela lemak selamanya?
Good news sebab saintis telah menemui bahawa flavonoids dalam buah2 citrus ni boleh 'memecahkan' baju besi perlindungan diorang tu. (Although further study still needed).
Makanlah banyak buah2 citrus macam oren, limau mandarin, lemon, grapefruit, limau kasturi, limau nipis, etc. Toksahlah minum minuman ringan walaupun nama dia "Diet" "Zero" ke apa ke. Semua tu useless. Minum jus limau kasturi je. (Feveret kitorang kalau pi kedai, order "limau kosong (no sugar) suam dua!".
Rujukan:
1. N. C. Cook and S. Samman, “Review: flavonoids-chemistry, metabolism, cardioprotective effects and dietary sources,” Journal of Nutritional Biochemistry, vol. 7, no. 2, pp. 66–76, 1996.
2. E. J. Middleton, “Effect of plant flavonoids on immune and inflammatory cell function,” Advances in Experimental Medicine and Biology, vol. 439, pp. 175–182, 1998.
3. E. Tripoli, M. L. Guardia, S. Giammanco, D. D. Majo, and M. Giammanco, “Citrus flavonoids: molecular structure, biological activity and nutritional properties: a review,” Food Chemistry, vol. 104, no. 2, pp. 466–479, 2007
4. Kern P, Di Gregorio G, Lu T, Rassouli N, Ranganathan G. Perilipin expression in human adipose tissue is elevated with obesity. J Clin Endocrinol Metab. 2004;89:1352–1358. doi: 10.1210/jc.2003-031388
5. Wang Y, Sullivan S, Trujillo M, Lee M, Schneider SH, Brolin RE, Kang YH, Werber Y, Greenberg AS, Fried SK. Perilipin expression in human adipose tissues: effects of severe obesity, gender and depot. Obes Res. 2003;11:930–936. doi: 10.1038/oby.2003.128
6. Dallas C, et al. Clinical study to assess the efficacy and safety of a citrus polyphenolic extract of red orange, grapefruit, and orange (Sinetrol-XPur) on weight management and metabolic parameters in healthy overweight individuals. Phytother Res. 2014 Feb;28(2):212-8. doi: 10.1002/ptr.4981.
7. Ray H, et al. Depot-specific differences in perilipin and hormone-sensitive lipase expression in lean and obese. Lipids Health Dis. 2009 Dec 18;8:58. doi: 10.1186/1476-511X-8-58.
8. Kern P, Di Gregorio G, Lu T, Rassouli N, Ranganathan G. Perilipin expression in human adipose tissue is elevated with obesity. J Clin Endocrinol Metab. 2004;89:1352–1358. doi: 10.1210/jc.2003-031388.
9. Assini JM, et al. Citrus flavonoids and lipid metabolism. Curr Opin Lipidol. 2013 Feb;24(1):34-40. doi: 10.1097/MOL.0b013e32835c07fd
10. K. P. Kell, A. M. Manadi, Z. F. Adiyasora, R. M. Kunaera, I. Z. V. Akad, and S. S. R. Naun, “Bioflavonoids and health effects in man,” Chemical Abstracts, vol. 107, pp. 366–367, 1987
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